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Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees

《环境科学与工程前沿（英文）》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1628-x

摘要：

● Metabolome can distinguish pregnant women exposure to PFOA at different degrees.

关键词： Perfluorooctanoic acid     Exposure     Pregnant women     Metabolomic     GSH     Microbiota metabolism    

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HIV感染孕产妇婚育状况分析

沙吾力·艾力卡,王晓军,艾比拜·买买提明

《中国工程科学》 2014年 第16卷 第5期   页码 60-62

摘要：

本文旨在了解新疆人体免疫缺陷病毒（HIV）感染孕产妇的婚育状况，从而为在感染孕产妇中开展生殖健康教育提供依据，笔者利用2010—2012 年间在预防艾滋病母婴传播管理信息网络直报系统中报告的HIV感染孕产妇个案卡资料进行分析。结果显示：1 692 例感染孕产妇平均年龄为29.03 岁，其中20～29岁的小年龄组孕产妇占53.31 %；传播途径为性传播的占60.52 %；婚姻状况初婚者占多数，但再婚者占一定比例（36.40 %）；两次及以上妊娠者占70.69 %，最多达10 次，但有两次及以上分娩经历者占19.92 %。由此可以看出，新疆HIV感染孕产妇中再婚比例明显高于全国其他省（自治区），终止妊娠者占一定比例，因此在女性感染者中有针对性地开展生殖健康教育活动势在必行。

关键词： HIV感染孕产妇     女性感染者     婚内传播     生殖健康    

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2010—2013年新疆HIV感染孕产妇妊娠结局分析

沙吾力·艾力卡,艾比拜·买买提明,王晓军

《中国工程科学》 2015年 第17卷 第6期   页码 50-52

摘要：

旨在了解新疆HIV感染孕产妇妊娠结局 。利用2010—2013年间在预防艾滋病母婴传播管理信息网络直报系统中报告的HIV感染孕产妇个案卡资料进行分析。2 256例HIV感染孕产妇平均年龄29.1岁，以维吾尔族为主，占90.65 %，初中及以下文化程度者占72.07 %，无业和农民占82.36 %（其中无业者占47.30 %），初婚占56.12 %，再婚占37.19 %。2次及以上妊娠者占69.68 %，有316例HIV感染孕产妇在知道自己的感染状况后仍然选择妊娠，占总数的14.01 %；再次妊娠的HIV感染孕产妇中人工终止妊娠的比例明显高于第一次接受服务的HIV感染孕产妇，两者有统计学差异（χ2=141.14，P=0.000）。新疆HIV感染孕产妇知道自身感染情况后仍有选择再次妊娠者，再次妊娠者中选择人工终止妊娠的比例明显高于第一次妊娠者，提示意外妊娠的存在，建议加强HIV感染妇女预防艾滋病母婴传播咨询服务和避孕指导，减少意外妊娠的发生，使HIV感染女性能够了解相关知识从而能够做出正确的生育或妊娠选择。

关键词： HIV感染孕产妇     非意愿性妊娠     生殖健康    

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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safelyand successfully become pregnant---a Chinese retrospective cohort study among 148 cases

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

《医学前沿（英文）》 2018年 第12卷 第5期   页码 509-517 doi: 10.1007/s11684-017-0554-3

摘要：

This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P=0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P<0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.

关键词： malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

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广州市2 046例孕前育龄妇女TORCH检查状况分析

余志衡

《中国工程科学》 2014年 第16卷 第5期   页码 63-66

摘要：

采用酶联免疫吸附试验(ELISA) 对2013 年1 月—2013 年12 月进行孕前筛查和孕早期普查的2 046 例妇女进行TORCH 特异性IgM 和IgG 抗体检测，主要检测RV-IgG、TOXO-IgG、TOXO-IgM、CMVIgG、CMV-IgM 五项。在调查的2 046 例妇女中，TORCH-IgM 总阳性率为0. 88 %，其中以巨细胞病毒(CMV)感染率居高，为0.68%，弓形虫（TOXO）为0. 20%。TORCH－IgG 阳性率以CMV最高，达97.65 %，其次为RV-IgG、TOXO-IgG，分别为85.58 %和4.89 %。广州市孕前和孕早期妇女TORCH感染率较高，应该积极进行监测和宣传，早发现，早干预，提高出生人口素质，减少出生缺陷与残疾发生。

关键词： TORCH     感染率     酶联免疫吸附试验     出生缺陷     孕前检查    

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A survey of physical activity among urban women in China

Shilin DENG MD, Tongyuan LIU,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 463-469 doi: 10.1007/s11684-009-0081-y

摘要： Few studies have been conducted to assess the level of physical activity (PA) of women in China. The purpose of this study was to describe the prevalence of PA among women in Wuhan and explore sociodemographic and behavioral correlation to PA for the population. A total of 1359 community-dwelling women (42.9713.60 years old) participated in this study. The long-version IPAQ was used to define the level of PA. 45.7% of women were considered physically active, and 27.5% were vigorously active. The proportion of physical inactivity was around 26.8%. The total and 4 domains of PA showed significant age, education level, and occupation variation. PA tended to be lower as the age declined. PA in transportation, housework, leisure time, and the total tended to be the lowest or the second lowest among the women aged 18–35 years old. PA tended to be lower as the level of education increased. Among the 5 indices, PAwas the lowest among women with college education, especially those with postgraduate education. PA tended to be the lowest among the women of office staff and instructor or technician. Generally, the total and 4 domains of PA showed significant age, education level, and occupation variation. Physical inactivity appears to be more common among younger women, or college-educated women, office ladies, and female instructor and technicians.

关键词： physical activity     urban women     China    

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Effects and mechanisms of acupuncture on women related health

《医学前沿（英文）》 doi: 10.1007/s11684-023-1051-5

摘要： Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when socioeconomic status is ignored. Women’s health has become a major public health concern, for those women from developing countries are still struggling with infectious and labor-related diseases, and their counterparts in developed countries are suffering from physical and psychological disorders. In recent years, complementary and alternative medicine has attracted wide attentions with regards to maintaining women’s health. Acupuncture, a crucial component of traditional Chinese medicine, has been used to treat many obstetric and gynecological diseases for thousands of years due to its analgesic and anti-inflammatory effects and its effects on stimulating the sympathetic/parasympathetic nervous system. To fully understand the mechanism through which acupuncture exerts its effects in these diseases would significantly extend the list of available interventions and would allow for more reasonable advice to be given to general practitioners. Therefore, by searching PubMed and CNKI regarding the use of acupuncture in treating obstetric and gynecological diseases, we aimed to summarize the proven evidence of using acupuncture in maintaining women’s health by considering both its effectiveness and the underlying mechanisms behind its effects.

关键词： acupuncture     women health     clinical efficacy     mechanism    

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Recombinant protein diannexin prevents preeclampsia-like symptoms in a pregnant mouse model via reducing

《医学前沿（英文）》 2022年 第16卷 第6期   页码 919-931 doi: 10.1007/s11684-021-0918-6

摘要： Preeclampsia (PE) is characterized by placenta-mediated pregnancy complication. The only effective treatment for PE is the delivery of the placenta. However, this treatment may cause preterm birth and neonatal death. Therefore, preventing PE is needed. The mechanism of PE involves abnormal placentation, which leads to the release of anti-angiogenic and inflammatory mediators into maternal circulation. These mediators contribute to systemic vascular dysfunction, inflammatory responses, and excessive thrombin generation. Microparticles (MPs) are reportedly involved in PE by promoting the thromboinflammatory response. This study describes a strategy to prevent PE by reducing MP release using the recombinant protein, diannexin. Results showed that the patients with PE had elevated MP number and procoagulant activity and increased NLRP3 inflammasome activation. Additionally, diannexin remarkably reduced the release of MPs from activated cells by binding to phosphatidylserine exposed on the surface of activated cells. Moreover, in vivo results showed that diannexin could prevent PE-like symptoms by decreasing MPs and NLRP3 inflammasome activation in pregnant mice. Furthermore, diannexin effectively inhibited trophoblast cell activation and NLRP3 inflammasome activation in vitro. These findings suggested that diannexin inhibited MP release and might be an effective therapeutic strategy for preventing PE.

关键词： preeclampsia     recombinant protein diannexin     microparticle     NLRP3 inflammasome     phosphatidylserin    

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Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 82-89 doi: 10.1007/s11684-015-0376-0

摘要：

Our preliminary studies demonstrated that Metacavir has potential to become a new anti-HBV agent. The main targets of the toxic effects of Metacavir, in rhesus monkeys, were gastrointestinal tracts, liver, blood, and kidneys, which were not related to mitochondrial effects. In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studied in pregnant Sprague-Dawley rats after intragastric administration of Metacavir (200, 100, 50, 0 mg/kg body weight) during the first 6–15 days of pregnancy. Slower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of 20 subjected to a 100 mg/kg dose. Compared with the solvent control group, the calibration weight gain in the 200 mg/kg and 100 mg/kg dosage groups respectively, during first 6–20 pregnant days were significantly different (P<0.01, P<0.05). Significant dose related adverse effects to other reproductive parameters were not seen in F0 and F1, but the number of stillbirths in high dose group showed notably difference compared with the control group (P<0.05), while the litter incidence showed no difference. No Metacavir-associated pathological changes were observed. The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dose in rats), Metacavir shows some maternal toxicity to SD rats. The embryotoxicity in the 200 mg/kg group encompass decreased fetal body weight, and higher fetal mortality rates, compared with the control group. However, the litter incidence showed no statistical difference. All the treated rats displayed normal bone development, no teratogenicity and without adverse effects on fetal development, thus indicating that below a dose of 200 mg/(kg·d) there is no teratogenic side effects.

关键词： deoxyguanosine analogue     Metacavir     pregnancy     maternal toxicity     embryo toxicity     teratogenicity    

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 323-329 doi: 10.1007/s11684-009-0061-2

摘要： The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

关键词： early postmenopausal women     bone mineral density     exercise     effects    

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免费孕前优生健康检查对象潜在危险因素接触和妊娠结局分析

车焱,周公望,王彩琴,张焕玲,张建娥,闫立新,陆珍,陆梅,沈洁,朱昊平

《中国工程科学》 2014年 第16卷 第5期   页码 56-59

摘要：

分析并报告上海市静安区免费孕前优生健康检查后待孕夫妇不良妊娠结局潜在影响因素接触情况以及妊娠率和妊娠结局，为免费孕前健康检查政府实施项目效果的评估提供基础数据。对2011 年8 月—2012 年11 月在静安区参加免费孕前优生健康检查的所有对象在其检查结束后的3 个月、6 个月、12 个月进行随访，重点关注不良妊娠结局潜在危险因素接触情况以及妊娠时间和妊娠结局。统计方法为χ2检验、寿命表、Logistic 回归分析。在目标时段内共有1 480 对夫妇参加了免费孕前优生健康检查，其中1 249 对服务对象接受了随访，随访率为84.4 %。截至2013 年4 月，48.7 %的随访对象已经受孕，孕前检查后3 个月调查累积妊娠率为23.9 %，6 个月调查累积妊娠率为45.0 %。365 人完成妊娠结局的随访，结果显示，早产率为3.0 %，低出生体重率为4.3 %，巨大儿发生率为3.3 %。自然流产率为6.3 %。另外，发现出生缺陷1 人，占妊娠妇女数的0.16 %，占有妊娠结局妇女数的0.27 %。烟酒等不良生活习惯丈夫的比例（18 %～20 %）高于妻子（1 %～3 %），77 %的丈夫和妻子接受潜在电磁辐射的时间超过8 h。9 %的夫妇自述生活和工作中接触重金属以及农药、化肥等潜在致畸物。超过10 %的妻子在怀孕以后接触了潜在致畸物。初步分析未发现上述因素与不良妊娠结局的关系。静安区孕前健康检查后半年内妇女妊娠率不到50 %，有必要在上海乃至全国开展免费孕前健康检查的成本效益评估。

关键词： 孕前优生健康检查     妊娠率     累积妊娠率     不良妊娠结局     危险因素    

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农村绝经后妇女性生活满意度及其影响因素分析

景秀,杨继高,刘俊,张丽华

《中国工程科学》 2014年 第16卷 第5期   页码 105-109

摘要：

为了探索影响农村绝经后妇女性生活满意度的因素，从而为开展老年妇女保健提供科学依据，笔者于2012 年3—8 月采用多阶段随机抽样方法对重庆市5 个区县农村绝经后妇女采用统一方法进行问卷调查和体检。结果显示，重庆市农村绝经后妇女对目前性生活满意和不满意的分别占83.7 %和16.3 %。单因素分析显示，绝经后妇女性生活满意度与其婚姻状况、文化程度、家庭收入、家庭结构、是否患有妇科疾病、最近两周是否有生殖道不适、起居方式、是否需要性生活、性生活频率、老年性保健知识、自觉体力状态及自觉生活状态等12 个变量有关（P<0.05）；多因素Logistic 回归分析显示，分居方式（比值比（OR）=1.711，95 %置信区间（CI）为1.334～2.194）、性生活频率高（OR=1.694，95 % CI 为1.334～2.152）、自觉体力状态差（OR=1.281，95 % CI 为1.018～1.613）是危险因素，家庭收入高（OR=0.651，95 % CI 为0.512～0.826）和既往有妇科疾病（OR=0.689，95 % CI 为0.486～0.977）是保护因素。因此，农村存在多种影响绝经后妇女性生活满意度的相关因素，应重视对绝经后妇女的性教育，改善她们的生活质量。

关键词： 绝经后妇女     性生活满意度     影响因素     Logistic分析    

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 459-462 doi: 10.1007/s11684-009-0084-8

摘要： The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in women under 30 years old with cervical intraepithelial neoplasia (CIN) or cervical cancer, in order to provide a basis for cervical cancer prevention and treatment. We recruited 2052 female cases from the education system in Futian District, Shenzhen city, from April 2006 to April 2008, with age ranging from 22 to 60 years old. Second-generation hybrid capture test was done for detection of female genital tract HPV and cervical colposcopy for screening CIN or cervical cancer. The prevalence of HPV and cervical precancerous lesions or cervical cancer was evaluated in different age groups of women. The HPV positive rate was 247/2052 (12.00%), and 35/2052 (1.71%) of the cases were≥CIN I by pathological diagnosis. In the 22―29-year-old age group, there were 291 cases, including 39HPV-positive cases (13.40%) and one case of pathological diagnosis≥CIN I (0.34%), and there were 1761 cases in the 30―60-year-old age group, including 208 HPV-positive cases (11.81%) and 34 cases of pathological diagnosis≥CIN I (1.93%). The HPV-positive rate of 22―29-year-old age group was higher than that of 30―60-year-old age group, but the difference was not significant ( = 0.5967, = 0.4398); the CIN and cervical cancer detection rate of the former group was lower than that of the latter one, and the difference was not significant either ( = 3.7519, = 0.0527). The cases in 30―60-year-old age group were divided into five age sub-groups, and the HPV-positive rate of the 22―29-year-old age group was compared with the remaining groups, and it was found that the HPV-positive rate of the former group (13.40%) was lower than that of the 40―44-year-old age group (14.70%) but higher than that of the other four groups. Moreover, the difference in the HPV-positive rate between the 22―29-year-old age group and the 50―60-year-old age group (6.06%) was significant ( = 5.545, = 0.018), but the difference between the 22― 29-year-old age group and each of the other four groups was not significant (>0.05). In addition, the CIN and cervical cancer detection rate of the 22―29-year-old age group (0.34%) was lower than that of the remaining five groups, and the difference between the 22―29-year-old age group and the 35―39-year-old age group (2.26%), and between 22―29-year-old age group and 40―44-year-old age group (2.30%) was significant ( = 4.446, = 0.0035; = 4.525, = 0.0363, respectively), but the difference between the 22―29-year-old age group and each of other three groups was not significant (>0.05). Furthermore, 80.00% (28/35) cases of pathological diagnosis≥CIN I and 90.91% (10/11) lesions of pathological diagnosis≥CIN II occurred at 35―49 years of age. For many young women below the age of 30 who were infected with high-risk HPV were one-off infections, so it was not appropriate to recommend HPV detection as cervical precancerous lesions or cancer screening program for women less than 30 years old. The prevention and treatment of cervical cancer should be focused on those women more than 35 years of age.

关键词： cervical cancer     human papilloma virus     cervical intraepithelial neoplasia    

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天津滨海新区产后妇女对避孕相关问题的认知现状分析

秦丽艳

《中国工程科学》 2015年 第17卷 第6期   页码 53-56

摘要：

通过对天津滨海新区产后妇女对避孕相关问题的认知现状的调查分析，以期认识到提高产后妇女的整体避孕意识的必要性。采用自行设计问卷，由固定医师进行询问并填写问卷。产后妇女中81.9 %的人知道产后应该避孕，但只有46.9 %知道产后高危人工流产的危害，48.8 %的产后妇女没有避孕计划或打算3个月后再采取避孕措施，47.2 %的产后妇女计划或已于首次性生活采取避孕措施，其中学历高、职业为干部组、剖宫产的产后妇女避孕意识较好，258人（80.6 %）通过住院分娩或产后访视得知产后应避孕，207人（64.7 %）在产后避孕方法上首选避孕套。产后妇女选择长效可靠避孕措施的少，医护工作者应提高对产后妇女有关产后避孕的指导和宣传，提高产后妇女对避孕效果可靠措施的使用率，提高产后妇女的生活质量。

关键词： 产后妇女；避孕；人工流产    

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北京市剖宫产育龄妇女产后避孕意愿分析

沈洁,高丽丽,潘迎

《中国工程科学》 2014年 第16卷 第5期   页码 16-19

摘要：

为了了解北京市剖宫产术后妇女的避孕意愿及其影响因素，在北京市城、近、郊区采用分层整群抽样方法随机抽取2011 年7 月—2011 年12 月期间接受剖宫产手术的产妇364 名，进行问卷调查。采用卡方检验和多因素Logistic 回归方法对问卷调查结果进行分析。结果显示，被调查妇女平均年龄为（31±4.53）岁，剖宫产术后计划恢复性生活时间中位数为7 周。96.43 %的妇女对于产后可以采用的避孕方法并不清楚。仅有27.74 %的妇女表示产后会尽早或立即采取避孕措施，避孕套是妇女首选的产后避孕方法，占75.27 %。72.25 %的妇女没有避孕计划或要等到产后3 个月才开始避孕。62.64 %的妇女在剖宫产术后接受了避孕指导，医生推荐的产后避孕方法中避孕套占首位。医生强调剖宫产术后避孕的重要性、妇女具备正确产后避孕知识是妇女剖宫产术后尽早开始避孕的保护因素。剖宫产妇女对产后避孕服务有较高需求，希望在产前保健或产后访视时能得到专业人员的产后避孕咨询指导。剖宫产术后再次妊娠存在健康风险，剖宫产妇女产后尽早落实避孕措施应引起高度关注。建议尽快针对剖宫产妇女开展产后避孕服务，摸索适合北京的服务模式，以满足需求，减少产后非意愿妊娠的发生，降低剖宫产术后人工流产的风险。

关键词： 育龄妇女     剖宫产术后     产后服务     避孕    

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